Vayantis Seed Treatment | Syngenta US

Upon registration, a fungicide seed treatment containing a new active ingredient, picarbutrazox, will be marketed as Vayantis® seed treatment. The seed treatment is currently under regulatory review by the U.S. Environmental Protection Agency (EPA), and will offer a new mode of action, providing protection from Pythium and Phytophthora that are caused by oomycete plant pathogens. Vayantis will be used on corn and soybeans upon EPA approval.

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Technical Features
Upon registration, Vayantis is anticipated to provide:

  • Enhanced activity against the most damaging corn and soybean seedling disease, Pythium
  • Improved early-season seed germination and growth, resulting in more consistent stand establishment and growth
  • Greater intrinsic activity per gram compared to any competitor, including ethaboxam, as well as broader spectrum of activity on Pythium than ethaboxam
  • Strong activity alone, and greater Phytophthora protection in combination with CruiserMaxx® Vibrance® seed treatment, under heavy Phytophthora pressure
  • Greater yield potential, according to 2015-2017 Syngenta field trials:
    • In corn under heavy Pythium pressure1: +4.1 bushels per acre (bu/A) over Vibrance Cinco fungicide seed treatment alone and +6.6 bu/A over Acceleron® Standard
    • In soybeans under heavy Pythium pressure1: +2.9 bu/A over CruiserMaxx Vibrance
    • In soybeans under Phytophthora pressure2: +1 bu/A over CruiserMaxx Vibrance

Active Ingredient: Picarbutrazox
  • Belongs to the tetrazolyloximes chemical group of fungicides (FRAC code U17), with a new mode of action
  • Is unique to any class of chemistry in the seed treatment market for protection against Pythium in corn and Phytophthora and Pythium in soybeans
  • Has no known cross resistance to any other oomycete fungicide compounds
  • Will play a key role in broadening integrated pest management strategies through multiple, effective modes of action

Pythium and Phytophthora at a Glance

Pythium in corn Pythium in corn
OH, 2018
  • Pythium is one of the most damaging diseases in corn and soybeans because it often reduces plant stand
  • The trend toward reduced tillage is leaving more plant residue on the soil surface, which makes the soil underneath cooler and damper
    • Pythium thrives in cool, wet conditions and can cause lack of seedling establishment, vigor reduction and loss of plant stand
  • There is a trend toward earlier planting, which means planting into cooler, disease-infected soil
  • There are many species of Pythium found across the Midwest, and once soil is infected, it is infected forever
  • Studies estimate Pythium damping-off is the leading cause of yield loss within root rot and seeding disease for North American corn


Pythium in soybeans Phytophthora in soybeans
OH, 2018
  • Phytophthora root and stem rot are significant diseases in many areas where soybeans are grown
  • Phytophthora thrives in warm, wet conditions and can cause stand issues, reduced emergence, wilting and even plant death
  • Phytophthora is a leading soybean yield reducer in years with early, warmer, wetter conditions.
  • It can survive in the soil for up to 5 to 10 years


Picarbutrazox Under Heavy Pythium Pressure



Non-oomycete check
Non-oomycete check
Non-oomycete check

Non-oomycete check

Picarbutrazox provides root protection against heavy Pythium infection in corn (top row) compared to check treatments (bottom row) without oomycete fungicide protection. Larger, healthier plants have increased yield potential compared to check treatments.

Syngenta trial
Fishers, IN; June 2016

Picarbutrazox is Active on More Species of Pythium than Ethaboxam

The lower the value and the flatter the entire range of the curve, the stronger the molecule is against the range of isolates presented. As you can see on the left, the range of values across the 248 Pythium isolates for picarbutrazox is much flatter and lower overall as compared to the ethaboxam value range. This is the key difference between the two molecules; picarbutrazox has activity on all 248 isolates, whereas the range presented for ethaboxam has many values at or greater than 100 (this means they were not sensitive to ethaboxam) and therefore ethaboxam has no activity on these isolates and therefore offers no protection from them.
Syngenta 2018 trial
Vero Beach, FL
Picarbutrazox Activity on Phytophthora

Non-oomycete check
Non-oomycete check + picarbutrazox rate 1

Treated check (left) compared to the same treatment with the addition of picarbutrazox (right) under Phytophthora pressure. Picarbutrazox delivered stronger stands and healthier plants.
TNA053A3-2017US; Anne Dorrance
The Ohio State University Phytophthora Nursery
Custar, OH; June 2017
Download Supporting Documents
Vayantis Technical Bulletin
Vayantis Technical Bulletin

Vayantis is not currently registered for sale or use in the United States and is not being offered for sale. Approved label and SDS will be available upon product registration.

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